Accession Number : AD0723063

Title :   Extended Human Acceptability Study of Chloroquine/Primaquine Plus Diformyl DDS.

Descriptive Note : Rept. no. 8,

Corporate Author : OKLAHOMA STATE PENITENITARY MCALESTER

Personal Author(s) : Czerwinski,Anthony W. ; Desper,Paul C. ; Colmore,John P. ; Evensen,Kenneth L.

Report Date : 16 OCT 1970

Pagination or Media Count : 273

Abstract : Fifty healthy adult male volunteer subjects were given either chloroquine/primaquine plus placebo or chloroquine/primaquine plus 200 mg. WR-6798 in identical appearing capsules. Medication was given orally once weekly for 16 weeks and on the day following each dose of medication blood and urine specimens were collected for chloroquine and sulfane concentration levels, alkaline phosphatase and BUN. These results demonstrated that chloroquine/primaquine plus 200 mgm of WR-6798 is associated with an increased incidence of methemoglobinemia but the data does not define the mechanism by which chloroquine/primaquine plus WR-6798 causes methemoglobinemia. Other observed and measured parameters varied sporadically and could not be directly related to drug administration. (Author)

Descriptors :   (*ANTIMALARIALS, ACCEPTABILITY), QUINOLINES, AMINES, ALDEHYDES, CINCHONA ALKALOIDS, DOSAGE, TOXICITY, PHARMACOLOGY, BLOOD CHEMISTRY, BLOOD DISEASES, HUMANS

Subject Categories : PHARMACOLOGY

Distribution Statement : APPROVED FOR PUBLIC RELEASE

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